A bilayered elastomeric scaffold for tissue engineering of small diameter vascular grafts
نویسندگان
چکیده
منابع مشابه
Tissue engineering of small diameter vascular grafts.
Tissue engineering, using either polymer or biological based scaffolds, represents the newest approach to overcoming limitations of small diameter prosthetic vascular grafts. Their disadvantages include thromboembolism and thrombosis, anticoagulant related haemorrhage, compliance mismatch, neointimal hyperplasia, as well as aneurysm formation. This current review represents an overview about pr...
متن کاملTissue engineering of recellularized small-diameter vascular grafts.
A tissue-engineered small-diameter arterial graft would be of benefit to patients requiring vascular reconstructive procedures. Our objective was to produce a tissue-engineered vascular graft with a high patency rate that could withstand arterial pressures. Rat arteries were acellularized with a series of detergent solutions, recellularized by incubation with a primary culture of endothelial ce...
متن کاملA biphasic elastomeric scaffold for tissue engineering a small-diameter blood vessel
Introduction Scaffolds used for tissue engineering should mimic the native structure of target tissues, gradually degrade with tissue formation, and coexist in a mechanically dynamic environment (sustain and recover from various deformations without mechanical irritations to the surrounding tissues[1, 2]). In the anatomy of a native blood vessel, endothelial cells are separated from surrounding...
متن کاملElectrospun Bilayered Vascular Scaffolds for Engineering Small Diameter Blood Vessels
336 ©2013 Society For Biomaterials
متن کاملNovel biphasic elastomeric scaffold for small-diameter blood vessel tissue engineering.
Compliance mismatch, thrombosis, and long culture times in vitro remain important challenges to the clinical implementation of a tissue-engineered small-diameter blood vessel (SDBV). To address these issues, we are developing an implantable elastomeric and biodegradable biphasic tubular scaffold. The scaffold design uses connected nonporous and porous phases as a basis to mimic, respectively, t...
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ژورنال
عنوان ژورنال: Acta Biomaterialia
سال: 2010
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2009.06.026